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KMID : 0939920210530030829
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대한암학회지
2021 Volume.53 No. 3 p.829 ~ p.836
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Performance and Diagnostic Accuracy of Human Papillomavirus Testing on Self-Collected Urine and Vaginal Samples in a Referral Population
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Cho Hyun-Woong
Hong Jin-Hwa
Min Kyung-Jin
Ouh Yung-Taek
Seong Seok-Ju
Moon Jun-Hye
Cho Seong-Hwan
Lee Jae-Kwan
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Abstract
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Purpose: The study aimed to evaluate the diagnostic accuracy of polymerase chain reaction?based high-risk human papillomavirus (HPV) assays on self-collected vaginal and urine samples for detection of precancerous cervical lesions in referral population.
Materials and Methods: Women referred for colposcopy following abnormal cytology, were included this study. A total of 314 matched urine, vaginal, and cervical samples were collected. All samples were tested for HPV DNA using the RealTime HR-S HPV and Anyplex II HPV 28 assays. Primary endpoints were sensitivity for cervical intraepithelial neoplasia (CIN) 2+/CIN3+ and specificity for
Results: The sensitivity of Realtime HR-S and Anyplex HPV assay was 93.13% (95% confidence interval [CI], 87.36 to 96.81) and 90.08% (95% CI, 83.63 to 94.61) for CIN2+ (n=130); specificity for
Conclusion: The detection performance for hrHPV and CIN2+ on self-collected vaginal samples was comparable to that of clinician-collected cervical samples. On the other hand, HPV tests using urine were inferior to those using clinician-collected cervical samples in terms of detecting hrHPV and CIN2+.
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KEYWORD
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Cervical intraepithelial neoplasia, Human papillomavirus DNA tests, Specimen handling, Urine
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